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Latrunculin A
The latrunculin class of marine sponge derived natural products represent one of the most potent and widely used molecular probes involving microfilament assembly that target G-actin in cell and molecular biology studies.
Source: Cacospongia mycofijiensis
Purity: >98% (HPLC) MW: 421.5 MF: C22H31NO5S CAS No. 76343-93-6
Product availability: 1 mg, 5 mg, 10 mg, 20 mg - $500 / 1mg
PRODUCTS
We serve as a high quality wholesale distributor of discounted marine sponge-derived natural products using advanced purification and spectroscopic methods which we have published previously (1-5). Purity is assured using LC-MS and 1H NMR data included with every product. We specialize in a select number of the most potent marine natural product inhibitors of the cell cycle which include the following wholesale discounted products.
CONTACT US for a FREE 100 ug Promotional Sample to confirm our Certificate of Analysis.
F- actin
Jasplakinolide
G- actin
Jasplakinolide is one of the most potent molecular probes for the inhibition of microfilament assembly targeting F-actin.
Source: Jaspis splendens
Purity: >98% (HPLC) MW: 709.1 MF: C36H45BrN4O6 CAS No.102396-24-7
Product availability: 1 mg, 5 mg, 10 mg, 20 mg - $1000 / 1mg
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Laulimalide (syn. fijianolide B) is a novel molecular probe microtubule stabilizer that functions at a binding site distinct from Taxol. It is a potent inhibitor of cellular proliferation in various cancer cell lines (IC50: 3-30 nM). The compound causes cells to arrest in prometaphase of the cell cycle, prevents formation of the bipolar spindle and increases kinetochore tension in preformed spindles.
Purity: >98% (HPLC) MW: 514.6 MF: C30H42O7 CAS No.115268-43-4
Produce availability: 1 mg - $2000 / 1mg (contact us for pricing)
Microtubule stabilizer
Laulimalide (syn. fijianolide B)
1) Bennett, M. J.; Chan, G. C.; Rattner, J. B.; Schreiemer, D. C.
Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization
Cell Cycle, 2012, 11, 3045.
2) Johnson, T. A.; Sohn, J.; Inman, W.D.; Estee, S. A.; Loveridge, S. T.; Vervoort, H. C.; Tenney, K.; Liu, J.; Ang, K. K.; Ratnam, J.; Bray, W. M,; Gassner, N. C.; Shen, Y. Y.; Lokey, R. S.; McKerrow, J. H.; Boundy-Mills K.; Nukanto, A.; Kanti, A.; Julistiono, H.; Kardono, L. B.; Bjeldanes, L. F.; Crews P.
Natural Product Libraries to Accelerate the High-Throughput Discovery of Therapeutic Leads.
Journal of Natural Products, 2011, 74, 2545.
3) Johnson, T. A.; Morgan, M.; Aratow, N.; Estee, S. A.; Sashidhara, K. V.; Loveridge, S.; Segraves, N. L.; Crews, P.
Assessing Pressurized Solvent Extraction for the High-Throughput Extraction of Marine-Sponge-Derived Natural Products.
Journal of Natural Products, 2010, 73, 359.
4) Amagata, T.; Johnson, T.A.; Cichewicz, R.H.; Tenney, K.; Mooberry, S.L.; Media, J.; Edelstein, M.; Valeriote, F.A.; Crews, P.
Interrogating the Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonomically Unrelated Sponges.
Journal of Medicinal Chemistry, 2008, 28, 7234.
5) Johnson, T.A.; Tenney, K.; Cichewicz, R.H.; Morinaka, B.I.; White, K.N.; Amagata, T.; Subramanian, B.; Media, J.; Mooberry, S.; Valeriote, F.A.; Crews, P.
Sponge-derived Fijianolide (syn. Laulimalide) Polyketide Class: Further Evaluation of their Structural and Cytotoxic Properties.
Journal of Medicinal Chemistry, 2007, 16, 3795.
